LY6E level associated with smoking as risk for lung cancer patients susceptible to COVID-19

نویسندگان

چکیده

Studies revealed that cancer patients seemed more susceptible to COVID-19 and the clinical symptoms were serious. A recent study depicted lymphocyte antigen 6 complex, locus E (LY6E) might inhibit coronavirus entry into cells by interfering with membrane fusion process mediated through spike protein, potently restricting SARS-CoV-2 (Severe acute respiratory syndrome-associated 2) infection. LY6E mRNA level in lung was detected publicly available datasets. Patient-specific features used analyze potential factors could affect level. Analysis of association between immune infiltration also performed. In present study, it found smoker adenocarcinoma showed lower than non-smoker (p < 0.05). LUSC (lung squamous cell carcinoma) patients, reformed smokers higher These results suggested smoke can be a risk patients. Further studies exhibited positively associated adenocarcinoma, indicating may influence infection severity summary, downregulate exacerbate deterioration

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ژورنال

عنوان ژورنال: Journal of Men's Health

سال: 2023

ISSN: ['1875-6867', '1875-6859']

DOI: https://doi.org/10.22514/jomh.2023.044